Abstract: In order to promote the overall improvement of transportation capacity in the 12.5 meters deep water channel of the Yangtze River,it is important to increase the controlled draft in regulations of large ocean-going vessels entering Nanjing Port timely and appropriately,In view of this,based on the construction effectiveness of the 12.5 meters deep water channel and the analysis of the navigation environment from the Nanjing to Jiangyin section of the Yangtze River,considering the water level,tidal conditions,and factors affecting the safety of ocean-going vessels navigation and berthing from Nanjing to Jiangyin section of the Yangtze River,this article proposes elevation scheme of controlled draft,designs ship maneuvering simulation tests and real ship tests for verification,and provides reference for over-draft Panamax bulk carrier with exceeding 11.36 meters draft to entering and berthing at Nanjing Port.